a Record control number 000321433400010

a ISSN 1752-6981

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WF100

b Item number .A87 2013

a Personal name Rasmussen, Finn,

h Medium Electronic Document

a Title Associations between airway hyperresponsiveness, obesity and lipoproteins in a longitudinal cohort

c Statement of responsibility, etc Finn Rasmussen, Robert J. Hancox, Parameswaran Nair, Henrik Steen, Hans Christian Siersted, Mads Nybo.

b Name of publisher, distributor, etc Wıley-Blackwell,

c Date of publication, distribution, etc 2013.

a Summary, etc Background Epidemiological data have linked obesity with an increased risk of asthma, but the mechanisms responsible for this relationship remain unknown. One possible mechanism, which has received little attention, could be the effect of cholesterol metabolism on airway smooth muscle function. The present study investigated the association between airway hyperresponsiveness (AHR) to methacholine and body mass index (BMI) and plasma lipoproteins [low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol]. Methods Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years. Results In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR at age 20 in both sexes (P<0.05). HDL, LDL/HDL ratio and total cholesterol were not associated with AHR. In multiple regression analyses adjusted for sex, lung function, smoking and asthma, only higher levels of BMI at age 14 or 20 years were significantly associated with increased AHR at age 20 years, while neither LDL, HDL and LDL/HDL ratio nor total cholesterol were significantly associated with AHR.Conclusion We confirmed that in teenagers there is a strong association between BMI and AHR to methacholine. This association seems to be independent of the plasma lipoprotein levels at that age.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Respiratory System

a Topical term or geographic name as entry element airway hyperresponsiveness;

a Topical term or geographic name as entry element Cholesterol

a Topical term or geographic name as entry element cohort studies;

a Topical term or geographic name as entry element Odense Schoolchıld

g Relationship information JUL 2013, Volume:7, Issue:3, Pages: 268-275

t Title Clınıcal Respıratory Journal

x International Standard Serial Number 17526981

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1111/crj.12000